Perioperative medicine & outcomes
Cardiopulmonary exercise testing before and after intravenous iron in preoperative patients: a prospective clinical study
Authors' conclusion
Preoperative administration of intravenous iron to iron-deficient/deplete anemic patients is associated with increases in [Hb], tHb-mass, peak oxygen consumption, and peak work rate.
Study context
- Population
- Preoperative patients having routine cardiopulmonary exercise testing (CPET) with [Hb] < 130 g.l-1 and iron deficiency/depletion20 completed
- Participants
- Twenty-six patients
- Exposure
- Before vs after i.v. ferric derisomaltose
- Outcome
- Hematological and CPET variables before vs after i.v. iron
- Follow-up
- 25 ± 7 days between baseline and the final visit
Methodological detailsbefore-after, 6 withdrew prior to study completion
- Before-after
- 6 withdrew prior to study completion
Main finding
As reported in the abstract
- [Hb] increased from 109 ± 14 to 116 ± 12 g l-1 (mean ± SD); mean rise 6.4%, p = < 0.0001, 95% CI 4.5-10.1
- 7.3 g l-1
- Total hemoglobin mass (tHb-mass) increased from 497 ± 134 to 546 ± 139 g; mean rise 9.3%, p = < 0.0001, 95% CI 29.4-69.2
- 49 g
- O2 AT did not change: 9.1 ± 1.7 to 9.8 ± 2.5 ml kg-1 min-1, 95% CI - 0.13 - 1.3
- p = 0.09
- O2 peak increased from 15.2 ± 4.1 to 16 ± 4.4 ml.kg.-1 min-1, 95% CI 0.2-1.8
- p = 0.02
- Peak work rate increased from 93 [67-112] watts to 96 [68-122] watts, 95% CI 1.3-10.8
- p = 0.02
Observational data: associations, not effects.
Original publication
Cardiopulmonary exercise testing before and after intravenous iron in preoperative patients: a prospective clinical study. Perioper Med (Lond). Published 3 July 2023. doi:10.
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