Perioperative medicine & outcomes
Preoperative aerobic fitness and perioperative outcomes in patients undergoing cystectomy before and after implementation of a national lockdown
Authors' conclusion
Lockdown measures in response to the COVID-19 pandemic were associated with a reduction in fitness and an increase in postoperative morbidity among patients undergoing radical cystectomy.
Study context
- Population
- Patients undergoing radical cystectomy with routine preoperative cardiopulmonary exercise testing (CPET)
- Participants
- 267 patients
- Exposure
- During lockdown vs pre-lockdown
- Lockdownn = 83
- Pre-lockdownn = 85reference
- Outcome
- Preoperative aerobic fitness (CPET variables)
Methodological detailsbefore-after comparison, univariate analysis
- Before-after comparison
- Univariate analysis
Main finding
As reported in the abstract
Ventilatory anaerobic threshold, median [IQR]
9.0 [7.9-10.9] vs 10.3 [9.1-12.3] ml kg-1 min-1
P = 0.0002
Lockdown
Peak oxygen uptake
15.5 [12.9-19.1] vs 17.5 [14.4-21.0] ml kg-1 min-1
P = 0.015
Lockdown
Ventilatory equivalents for carbon dioxide
34.7 [31.4-38.5] vs 33.4 [30.5-36.5]
P = 0.030
Lockdown
Observational data: associations, not effects.
Further findings
| Outcome | Lockdown | Pre-lockdown | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| Day 5 POMS-defined morbidityUnivariate analysis | 89% | 75% | 2.698 (1.143–6.653) | P = 0.019 | |
| Day 5 POMS pulmonary complicationsUnivariate analysis | 30% | 13% | 2.900 (1.368–6.194) | P = 0.007 | |
| Day 5 POMS painUnivariate analysis | 27% | 9% | 3.471 (1.427–7.960) | P = 0.004 | |
| 0.10.31310Odds ratio (log scale) |
Original publication
Preoperative aerobic fitness and perioperative outcomes in patients undergoing cystectomy before and after implementation of a national lockdown. BJA Open. Published 17 January 2024. doi:10.
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