Cardiothoracic & vascular anesthesia
Cell salvage volume and hemostatic changes in cardiac surgery: A retrospective cohort study using routine coagulation and viscoelastic assessment
Authors' conclusion
At observed reinfusion volumes, CS was not associated with changes in routine coagulation parameters, but in the exploratory viscoelastic cohort, higher CS volume was associated with lower functional fibrinogen clot strength. These findings highlight the potential value of viscoelastic monitoring when higher volumes are anticipated.
Study context
- Population
- Adult patients undergoing cardiac surgery with cell salvage (CS) use, with paired hemostatic measurements and without coagulation-affecting blood products between measurementstwo cohorts with paired hemostatic measurements · routine coagulation cohort (primary analysis) 677 · viscoelastic cohort (exploratory analysis) 50
- Exposure
- CS volume and absolute changes in each parameter, adjusted for surgical and patient characteristics and baseline values
- Outcome
- Absolute changes in routine coagulation parameters (routine coagulation cohort, primary analysis)
Methodological detailsmultivariable linear regression, Holm correction for multiple testing
- Multivariable linear regression
- Holm correction for multiple testing
Main finding
As reported in the abstract
- CS volume not significantly associated with absolute changes in any parameter
- all p ≥ 0.144
Observational data: associations, not effects.
Further findings
| Outcome | β (mm/L) (95% CI) | P value |
|---|---|---|
| Functional fibrinogen clot strength (CFF MA), viscoelastic cohort (exploratory)After Holm correction adjusted p = 0.031 · exploratory analysis | −3.31 (−5.53 to −1.08) | P = 0.004 |
| Overall clot strength (CK MA), viscoelastic cohort (exploratory)After Holm correction adjusted p = 0.244 · exploratory analysis | −2.93 (−5.73 to −0.13) | P = 0.041 |
- Functional fibrinogen clot strength (CFF MA), viscoelastic cohort (exploratory) — β = −3.31 mm/L; 95% CI: −5.53, −1.08; p =
- 0.004
Original publication
Cell salvage volume and hemostatic changes in cardiac surgery: A retrospective cohort study using routine coagulation and viscoelastic assessment. J Clin Anesth. Published 31 October 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →