Neuroanesthesia & neurocritical care
Cerebral autoregulation derived blood pressure targets in elective neurosurgery
Authors' conclusion
It seems possible to assess individualised automated ABP targets during elective neurosurgery.
Study context
- Population
- Patients undergoing elective neurosurgerymedian age 60 (IQR 51–68)
- Participants
- 85 patients
- Outcome
- Availability of continuous automated COx-derived ABPOPT (ABP where cerebral autoregulation (CA) is best preserved) and LLA, time to first values, differences between ABPOPT/LLA and ABP
Methodological detailsABPBASELINE was the mean of 3 pre-operative non-invasive measurements
- ABPBASELINE was the mean of 3 pre-operative non-invasive measurements
Main finding
As reported in the abstract
- ABPOPT availability
- 86%
- Lower limit of autoregulation (LLA) availability
- 89%
- Median (IQR) time to first ABPOPT value, min
- 97 (80-155)
- Median (IQR) time to first LLA value, min
- 93 (78-122)
- Median ABPOPT vs ABPBASELINE: 75 (69-84) vs 90 (84-95), lower (Mann-U test)
- p < 0.001
- Recorded time with arterial blood pressure (ABP) above or below ABPOPT ± 5 mmHg, %
- 72 (56-86)
- Patients with ≥1 hypotensive insult (ABP < LLA)
- 37.6%
Observational data: associations, not effects.
Original publication
Cerebral autoregulation derived blood pressure targets in elective neurosurgery. J Clin Monit Comput. Published 19 January 2024. doi:10.
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