Neuroanesthesia & neurocritical care
Cerebral oxygenation when ventilated or spontaneously breathing: a randomised control trial
Authors' conclusion
Ventilatory strategy (IPPV vs spontaneous ventilation) did not have a statistically significant impact on cerebral oxygenation in this study.
Study context
- Population
- Patients undergoing arthroscopic shoulder surgeryall 40 analysed
- Participants
- 40 patients
- Comparison
- Spontaneous ventilation vs intermittent positive pressure ventilation (IPPV)
- Spontaneous ventilationn = 20reference
- IPPVn = 20
- Primary endpoint
- Time-averaged change in cerebral oxygenation
- Follow-up
- Intraoperative period
Methodological detailscerebral oximetry data blinded to treating anaesthetist, retrospectively registered
- Cerebral oximetry data blinded to treating anaesthetist
- Retrospectively registered
Primary result
As reported in the abstract
Intraoperative increase in cerebral oximetry · intraoperative
| Group | Value | Left hemisphere | Right hemisphere |
|---|---|---|---|
| Spontaneous ventilation | mean 10.5 (SD 7.62) | 10.5 | 12.6 |
| IPPV | mean 12.9 (SD 7.65) | 12.9 | 11.0 |
Value
Spontaneous ventilationmean 10.5 (SD 7.62)
IPPVmean 12.9 (SD 7.65)
Left hemisphere
Spontaneous ventilation10.5
IPPV12.9
Right hemisphere
Spontaneous ventilation12.6
IPPV11.0
- IPPV vs Spontaneous ventilation: P = 0.332 — left hemisphere
- IPPV vs Spontaneous ventilation: P = 0.427 — right hemisphere
Secondary outcomes
| Outcome | P value |
|---|---|
| Cerebral desaturation events (≥ 20% fall below baseline, or absolute value of 55% or less) | P = 0.155 |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Cerebral oxygenation when ventilated or spontaneously breathing: a randomised control trial. Perioper Med (Lond). Published 30 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →