Cerebrovascular Complications of COVID-19 on Venovenous Extracorporeal Membrane Oxygenation*
Authors' conclusion
Our study highlights the association of obesity and pre-ECMO vasopressor use with the development of stroke in COVID-19 patients on venovenous ECMO.
Study context
- Population
- Adult COVID-19 patients supported by venovenous extracorporeal membrane oxygenation (ECMO), 380 institutions in 53 countries (COVID Critical registry)
- Participants
- 595 patients
- Exposure
- Stroke vs no stroke
- Stroken = 43
- Outcome
- Stroke
Methodological detailsmulticentre registry, multivariable survival modelling (Cox and Fine-Gray), death and discharge as competing risks
- Multicentre registry
- Multivariable survival modelling (Cox and Fine-Gray)
- Death and discharge as competing risks
Main finding
As reported in the abstract
Stroke
7.2%
43
Adjusted hazard ratio (95% CI)
Obesity
2.19(1.05–4.59)
Vasopressors before ECMO
2.37(1.08–5.22)
- Hemorrhagic strokes
- 83.7%
Observational data: associations, not effects.
Further findings
In-hospital mortality
| Outcome | Stroke | Nonstroke |
|---|---|---|
| Relative ΔPaCO2 and ΔPaO2 · 48 hours after ECMO initiation | ||
| Relative ΔPaCO2 | negative 26% | negative 17% |
| Relative ΔPaO2 | positive 24% | positive 7% |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Cerebrovascular Complications of COVID-19 on Venovenous Extracorporeal Membrane Oxygenation*. Crit Care Med. Published 3 April 2023. doi:10.
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