Change in stroke volume during alveolar recruitment maneuvers through transient continuous positive airway pressure or stepwise increase in positive end expiratory pressure in anesthetized patients: a prospective randomized double-blind study
Primary result · Relative variation in stroke volumeResult — go to the resultDifference −25 95% CI −37 to −14Authors' conclusion
Alveolar recruitment maneuvers through stepwise increase and decrease in PEEP have a better hemodynamic tolerance than transient CPAP.
Study context
- Population
- Anesthetized patients scheduled for intermediate to high-risk surgery with continuous arterial pressure and stroke volume (esophageal Doppler) monitoring, preload independence of stroke volume ensured35 included in continuous positive airway pressure (CPAP) and STEP groups
- Comparison
- CPAP vs STEP
- Primary endpoint
- Relative variation in stroke volume
Methodological detailsprospective, single-centre, double-blind
- Prospective
- Single-centre
- Double-blind
Primary result
As reported in the abstract
Difference
−25
95% CI −37 to −14
P < 0.001
By group
CPAP
−57
mean · SD 24 · %
STEP
−32
mean · SD 24 · %
CPAP vs STEP
difference −25 (95% CI −37 to −14); P < 0.001
Further findings
Systolic, mean and diastolic arterial pressure changes over time
- Not different between groups
Safety
Events
| Outcome | CPAP | STEP |
|---|---|---|
| ARM stopped for SBP < 70 mm Hg | 4 | 1 |
Original publication
Change in stroke volume during alveolar recruitment maneuvers through transient continuous positive airway pressure or stepwise increase in positive end expiratory pressure in anesthetized patients: a prospective randomized double-blind study. Can J Anaesth. Published 28 November 2023. doi:10.
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