Cardiothoracic & vascular anesthesia
Changes of the nociceptive flexion reflex threshold in patients undergoing cardiac surgery—a prospective clinical pilot study
Authors' conclusion
NFRT values after surgery were higher compared to baseline measurements. Subsequently they decreased but did not reach their baseline levels.
Study context
- Population
- Patients undergoing cardiac surgery30 analysed
- Participants
- 55 patients
- Exposure
- Nociceptive flexion reflex threshold (NFRT) immediately after surgery and later on the general ward vs preoperative baseline
- Outcome
- Nociceptive flexion reflex threshold (NFRT) preoperatively, immediately after surgery and later in the general ward
Methodological detailsData collected August 2019 to March 2020, 264 patients screened, No intraoperative measurements (NMB hinders NFRT assessment)
- Data collected August 2019 to March 2020
- 264 patients screened
- No intraoperative measurements (NMB hinders NFRT assessment)
Main finding
As reported in the abstract
NFRT
TICU vs Tpre: P < 0.001 · Tpost vs Tpre: P = 0.043
- No immediate postoperative reflex response elicited
- 11 patients (36.7%)
Observational data: associations, not effects.
Secondary outcomes
Dose-dependency of NFRT on administered analgesics
- No corresponding dose-dependency
Original publication
Changes of the nociceptive flexion reflex threshold in patients undergoing cardiac surgery—a prospective clinical pilot study. J Clin Monit Comput. Published 24 December 2022. doi:10.
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