Chest CT findings in severe acute respiratory distress syndrome requiring V-V ECMO: J-CARVE registry
Authors' conclusion
Traction bronchiectasis and subcutaneous emphysema increased the risk of 90-day in-hospital mortality in patients with severe ARDS who required V-V ECMO.
Study context
- Population
- Patients with severe acute respiratory distress syndrome (ARDS) on V–V ECMO admitted to the ICUs of 24 hospitals in Japan, 2012–2022underwent chest CT
- Participants
- 582 patients
- Exposure
- Chest CT findings at V-V ECMO initiation and outcomes
- Survivedn = 394
- Diedn = 188
- Outcome
- In-hospital mortality
- Follow-up
- 90 days
Methodological detailsmulticentre, registry
- Multicentre
- Registry
Main finding
As reported in the abstract
90-day in-hospital mortality
Hazard ratio (95% CI)P value
Traction bronchiectasis
1.77(1.19–2.63)
P = 0.005Subcutaneous emphysema
1.97(1.02–3.79)
P = 0.044Observational data: associations, not effects.
Secondary outcomes
Successful liberation from V-V ECMO
| OR for successful liberation from V-V ECMO (CI) | P value | ||
|---|---|---|---|
| Traction bronchiectasisDecreased successful liberation | 0.27 (0.14–0.52) | P < 0.001 | |
| 0.10.31310OR for successful liberation from V-V ECMO (log scale) |
Static lung compliance
- Lower static lung compliance associated with some CT findings related to changes outside of pulmonary opacity, but not with findings related to pulmonary opacity
Original publication
Chest CT findings in severe acute respiratory distress syndrome requiring V-V ECMO: J-CARVE registry. J Intensive Care. Published 26 January 2024. doi:10.
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