Cardiothoracic & vascular anesthesia
Chlorhexidine-alcohol compared with povidone-iodine-alcohol skin antisepsis protocols in major cardiac surgery: a randomized clinical trial
Primary result · Reoperation within 90 daysResult — go to the resultRisk difference 0.25 95% CI - 1.58-2.07Authors' conclusion
Among patients requiring sternotomy for major heart or aortic surgery, skin disinfection at the surgical site using chlorhexidine-alcohol was not superior to povidone-iodine-alcohol for reducing reoperation and surgical site infection rates.
Study context
- Population
- Adults undergoing major heart or aortic surgery via sternotomy, with or without saphenous vein or radial artery harvesting, 8 French hospitals
- Participants
- 3,242 adults
- Comparison
- Chlorhexidine-alcohol vs Povidone-iodine-alcohol
- Chlorhexidine-alcoholn = 1,621
- Povidone-iodine-alcoholn = 1,621reference
- Primary endpoint
- Any resternotomy by day 90 or any reoperation at the peripheral surgical site by day 30
Methodological detailsmulticentre, open-label, two-arm, assessor-blind, superiority
- Multicentre
- Open-label
- Two-arm
- Assessor-blind
- Superiority
Primary result
Reoperation within 90 days
Risk difference
0.25
95% CI - 1.58-2.07
P = 0.79
Events by treatment group
As reported in the abstract
Further findings
| Outcome | Chlorhexidine-alcohol | Povidone-iodine-alcohol | Risk difference (95% CI) | P value | |
|---|---|---|---|---|---|
| Surgical site infections at the sternum or peripheral sites | 4% | 3.3% | 0.74 (- 0.55-2.03) | P = 0.26 | |
| −10123Difference (linear scale) |
Hospital LOS, ICU or hospital readmission, mortality
- Similar between the two groups
Safety
Surgical site adverse events
- Similar between the two groups
Original publication
Chlorhexidine-alcohol compared with povidone-iodine-alcohol skin antisepsis protocols in major cardiac surgery: a randomized clinical trial. Intensive Care Med. Published 12 November 2024. doi:10.
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