Choice of Anesthesia in Microelectrode Recording–guided Deep Brain Stimulation Surgery for Parkinson’s Disease (CHAMPION): A Noninferiority Randomized Controlled Trial
Primary resultResult — go to the resultDifference −0.96% 95% CI −9.62 to 7.70Authors' conclusion
General anesthesia is noninferior to conscious sedation for microelectrode-guided subthalamic nucleus deep brain stimulation, providing equivalent signal intensity and clinical outcomes while improving procedural efficiency
Study context
- Population
- Patients with Parkinson's disease (UK Brain Bank criteria) undergoing elective bilateral microelectrode recording–guided deep brain stimulation surgeryrandomized
- Participants
- 188 patients
- Comparison
- GA vs conscious sedation
- General anesthesian = 94
- Conscious sedationn = 93reference
- Primary endpoint
- Proportion of patients with high-quality microelectrode recording (normalized root mean square >2.0), assessed postoperatively off-line
Methodological detailsnoninferiority, prospective, 1:1 randomisation
- Noninferiority
- Prospective
- 1:1 randomisation
Primary result
As reported in the abstract
Difference
−0.96%
95% CI −9.62 to 7.70
By group
General anesthesia vs Conscious sedation
difference −0.96% (95% CI −9.62 to 7.70)
Secondary outcomes
| Outcome | Difference (min) (95% CI) | P value | |
|---|---|---|---|
| Operative time | −9.07 (−13.99 to −4.14) | P < 0.001 | |
| −20−10010Difference, min (linear scale) |
| Outcome | Difference (95% CI) | P value | |
|---|---|---|---|
| Change in Unified Parkinson's Disease Rating Scale score · 6 months | −2.50 (−7.20 to 2.20) | P = 0.297 | |
| −10−505Difference (linear scale) |
| Outcome | Difference (mg) (95% CI) | P value | |
|---|---|---|---|
| Change in levodopa equivalent daily dose · 6 months | −58.4 (−133.56 to 16.75) | P = 0.128 | |
| −200−1000100Difference, mg (linear scale) |
Safety
Complication rates · 6 months · comparable
P = 0.655
Original publication
Choice of Anesthesia in Microelectrode Recording–guided Deep Brain Stimulation Surgery for Parkinson’s Disease (CHAMPION): A Noninferiority Randomized Controlled Trial. Anesthesiology. Published 8 May 2026. doi:10.
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