Circuit change during extracorporeal membrane oxygenation: single-center retrospective study of 48 changes
Authors' conclusion
In patients with severe and persistent bleeding, changing the ECMO circuit decreased clinical bleeding and red blood cell transfusion needs and increased platelets and fibrinogen levels. Oxygenation parameters did not change significantly in the group with thrombosis.
Study context
- Population
- Patients on extracorporeal membrane oxygenator (ECMO) with circuit changes for bleeding or thrombosis, January 2017 to August 2020circuit changes in 44 patients
- Participants
- 48 patients
- Exposure
- Before vs after ECMO circuit change
- Bleedingn = 32
- Thrombosisn = 16reference
- Outcome
- Course of clinical, laboratory and transfusion parameters before and after ECMO circuit change
- Follow-up
- Seven days surrounding the circuit change
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Bleeding: bleeding events, hemostatic procedures and RBC transfusions significantly higher before vs after change
- P < 0.001
Observational data: associations, not effects.
Further findings
Mortality, bleeding vs thrombosis
P = 0.39
- Mortality, with vs without circuit changes: With changes 48%
- Mortality, with vs without circuit changes: Without changes 43%
Mortality, with vs without circuit changes
- Mortality similar
Original publication
Circuit change during extracorporeal membrane oxygenation: single-center retrospective study of 48 changes. Crit Care. Published 2 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →