Hemorrhages and risk factors in patients undergoing thromboprophylaxis in a respiratory critical care unit: a secondary data analysis of a cohort study
Authors' conclusion
Bleeding risk assessment models from the 9th ACCP guidelines may not be suitable for patients in RICU.
Study context
- Population
- Patients admitted to the respiratory ICU at Beijing Chao-Yang Hospital, August 2014 to December 2020, receiving thromboprophylaxis
- Participants
- 931 patients
- Comparison
- High vs low bleeding risk
- High riskn = 715
- Primary endpoint
- Major bleeding
- Follow-up
- Until discharge
Methodological detailssingle-centre
- Single-centre
Primary result
As reported in the abstract
Major bleeding, all patients
9.2%
86/931
Further findings
Blood transfusion not related to bleeding (protective factor for major bleeding)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Blood transfusion not related to bleeding | 0.099 (0.045–0.218) | P < 0.001 | |
| 0.050.21520Odds ratio (log scale) |
Mortality and LOS
- High-risk patients had poor outcomes, including higher mortality and longer stays
Independent risk factors for major bleeding
- APACHE II score ≥ 15; invasive pulmonary aspergillosis; therapeutic dose of anticoagulants; ECMO; CRRT
Original publication
Hemorrhages and risk factors in patients undergoing thromboprophylaxis in a respiratory critical care unit: a secondary data analysis of a cohort study. J Intensive Care. Published 29 October 2024. doi:10.
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