Pediatric anesthesia & critical care
Circulating High Mobility Group Box-1 Does Not Predict Pulmonary Arterial Hypertension in Children with Congenital Heart Disease: A Prospective Cohort Study
Authors' conclusion
Unlike in adults, HGMB1 is not a biomarker of PAH in pediatric CHD.
Study context
- Population
- Children ≤18 years with congenital heart disease (CHD) with and without known pulmonary hypertension, quaternary pediatric academic hospital
- Exposure
- Children with CHD with and without pulmonary hypertension vs controls without heart disease
- Outcome
- HMGB1 and NT-proBNP levels
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Neither HMGB1 nor NT-proBNP levels significantly different between the groups
- Neither marker correlated with pulmonary hypertension
Observational data: associations, not effects.
Further findings
- Pulmonary vascular resistance index in CHD-PAH
- 10 · mean · Wood units/m²
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Circulating High Mobility Group Box-1 Does Not Predict Pulmonary Arterial Hypertension in Children with Congenital Heart Disease: A Prospective Cohort Study. J Cardiothorac Vasc Anesth. Published 11 July 2024. doi:10.
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