Cirrhosis is an independent risk factor for candidemia in critically ill patients: A 6-year single-center observational study
Main finding · Candidemia in the ICU (total population)Result — go to the resultOdds ratio 2.28 CI 1.14–4.53Authors' conclusion
Cirrhosis emerged as an independent risk factor for candidemia in the ICU. Within the cirrhotic subgroup, a high Child-Pugh score emerged as the sole independent correlate.
Study context
- Population
- Critically ill patients in an ICU with a high volume of patients with cirrhosis, over 6 years37 developed candidemia
- Participants
- 1,985 patients
- Exposure
- Cirrhosis vs no cirrhosis as risk factor for candidemia in ICU
- Cirrhosisn = 416
- Outcome
- Risk factors for candidemia in the ICU
Methodological detailssingle-centre, consecutive inclusion
- Single-centre
- Consecutive inclusion
Main finding
Candidemia in the ICU (total population)
Odds ratio
2.28
CI 1.14–4.53
P = 0.019
Cirrhosis vs No cirrhosis
OR 2.28 (CI 1.14–4.53); P = 0.019
As reported in the abstract
Observational data: associations, not effects.
Further findings
Candidemia among patients with cirrhosis: high Child-Pugh score (subgroup)
| OR (CI) | P value | ||
|---|---|---|---|
| High Child-Pugh scoreSole independent correlate | 1.68 (1.10–2.67) | P = 0.021 | |
| 0.20.5125Odds ratio (log scale) |
| Outcome | Cirrhosis | P value |
|---|---|---|
| Candidemia-free survival by ACLF grade (post hoc)ACLF grade 2-3 vs ACLF grade 0-1 · log-rank; significantly lower · post hoc | P = 0.029 | |
| ICU mortality in patients with candidemia | 81.2% |
- ICU mortality in patients with candidemia: Total population 59.5%
ICU mortality in patients with candidemia
- Candidemia associated with higher ICU mortality
Original publication
Cirrhosis is an independent risk factor for candidemia in critically ill patients: A 6-year single-center observational study. Anaesth Crit Care Pain Med. Published 10 October 2025. doi:10.
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