Conservative versus liberal fluid resuscitation for septic patients at risk for fluid overload: A systematic review with meta-analysis
Authors' conclusion
Among patients with comorbid conditions presenting with sepsis, we found no differences in outcomes related to the volume of fluid administered.
Study context
- Population
- Adults with sepsis and congestive HF, CKD or cirrhosis37 observational studies
- Comparison
- Conservative vs liberal fluid resuscitation volumes
- Outcome
- All-cause mortality
- Follow-up
- Up to 30 days post-discharge
Pooled result
As reported in the abstract
All-cause mortality up to 30 days post-discharge
No statistically significant difference in all-cause mortality, conservative vs liberal volumes: OR
1.01
95% CI 0.86–1.19
Further pooled results
ICU admission
- No statistically significant difference: RR
- 0.89 (95% CI 0.70-1.11)
Hospital LOS
- No statistically significant difference: MD −0.01 (95% −0.18-0.15)
ICU LOS
- No statistically significant difference: MD
- −0.06 (95% CI −0.30-0.18)
Intubation rates
- No statistically significant difference: OR 1.00 (95% 0.76-1.32)
Duration of mechanical ventilation
- No statistically significant difference: MD
- 0.01 (95% CI −0.31-0.32)
Use of vasopressors
- No statistically significant difference: RR
- 0.81 (95% CI 0.64-1.02)
Original publication
Conservative versus liberal fluid resuscitation for septic patients at risk for fluid overload: A systematic review with meta-analysis. J Crit Care. Published 28 February 2025. doi:10.
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