Clinical characteristics and factors associated with ICU mortality during the first year of the SARS-Cov-2 pandemic in Romania: A prospective, cohort, multicentre study of 9000 patients
Authors' conclusion
The SARS-CoV-2 critically ill Romanian patients share common personal and clinical characteristics with published European cohorts.
Study context
- Population
- Patients with SARS-CoV-2 infection admitted to Romanian ICUs, March 2020 to March 2021definitive ICU outcome
- Participants
- 9,058 patients
- Outcome
- ICU mortality
Methodological detailsobservational, multicentre, national recruitment
- Observational
- Multicentre
- National recruitment
Main finding
As reported in the abstract
Factors associated with ICU mortality (multivariable mixed effects logistic regression)
Odds ratio (95% CI)
Age
1.27(1.23–1.31)
Male gender
1.21(1.05–1.4)
Neoplasia
1.74(1.36–2.22)
CKD
1.54(1.27–1.88)
Type II diabetes
1.23(1.06–1.43)
Chronic HF
1.24(1.03–1.49)
Dyspnoea
1.3(1.1–1.5)
SpO2 <90%
3(2.5–3.5)
Admission SOFA score
1.07(1.05–1.09)
ARDS on ICU admission
1.35(1.1–1.63)
Invasive ventilation
28(22–35)
Neuromuscular blockade
3.5(2.6–4.8)
Higher GCS on admission
0.81(0.79–0.83)
Hydroxychloroquine
0.78(0.64–0.95)
Tocilizumab
0.58(0.48–0.71)
- Noninvasive ventilation · CI as printed
- OR 1.8 (95% CI 1.5–1.22)
Observational data: associations, not effects.
Original publication
Clinical characteristics and factors associated with ICU mortality during the first year of the SARS-Cov-2 pandemic in Romania: A prospective, cohort, multicentre study of 9000 patients. Eur J Anaesthesiol. Published 16 November 2022. doi:10.
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