Characteristics of SARS-CoV-2-associated severe episodes of monoclonal gammopathy-associated capillary leak syndrome (Clarkson disease)
Main finding · 28-day mortalityResult — go to the resultOdds ratio 4.67 CI 1.08–20.1Authors' conclusion
In this large cohort of MG-CLS episodes requiring ICU admission, SARS-CoV-2as a trigger was associated with significantly higher 28-day mortality compared to other triggers.
Study context
- Population
- Patients with monoclonal gammopathy-associated capillary leak syndrome (MG-CLS) admitted to the intensive care unit (ICU)
- Participants
- 84 patients · 127 ICU admissions
- Exposure
- MG-CLS episodes triggered by SARS-CoV-2 vs other triggers
- SARS-CoV-2n = 26
- Outcome
- Mortality according to whether SARS-CoV-2 was identified as a trigger
- Follow-up
- 28 days
Methodological detailsmulticentre
- Multicentre
Main finding
28-day mortality
Odds ratio
4.67
CI 1.08–20.1
P = 0.04
By group
SARS-CoV-2 vs Other triggers
OR 4.67 (CI 1.08–20.1); P = 0.04
As reported in the abstract
Observational data: associations, not effects.
Further findings
Need for mechanical ventilation
P = 0.004
Need for RRT
P = 0.03
Overall 28-day mortality
- Patients who died within 28 days of ICU admission
- 32%
Intravenous immunoglobulins and 28-day survival
- IV immunoglobulins did not improve 28-day survival
Original publication
Characteristics of SARS-CoV-2-associated severe episodes of monoclonal gammopathy-associated capillary leak syndrome (Clarkson disease). Ann Intensive Care. Published 26 May 2025. doi:10.
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