Diaphragm function in patients with Covid-19-related acute respiratory distress syndrome on venovenous extracorporeal membrane oxygenation
Authors' conclusion
Sixty-two percent of patients undergoing ECMO for ARDS related to SARS CoV-2 infection had a diaphragm dysfunction on Day 1 of ECMO initiation. Diaphragm function remains stable over time and was not associated with the percentage of time with spontaneous breathing.
Study context
- Population
- Patients with acute respiratory distress syndrome (ARDS) related to SARS CoV-2 infection requiring VV ECMO, two centers
- Participants
- 63 patients · 2 centres
- Outcome
- Prevalence of diaphragm dysfunction (Ptr,stim ≤ 11 cmH2O on phrenic nerve stimulation)
- Follow-up
- Day 1 of ECMO
Methodological detailstwo-centre, serial assessment
- Two-centre
- Serial assessment
Main finding
As reported in the abstract
Diaphragm dysfunction (Ptr,stim ≤ 11 cmH2O)
Diaphragm dysfunction (Ptr,stim ≤ 11 cmH2O) on Day 1 of ECMO
39 patients
62%
Observational data: associations, not effects.
Further findings
Change in diaphragm function over the study period
- Diaphragm function did not change over the study period; not influenced by % spontaneous breathing ventilation or TFdi during the 1 week
Alive at end of study period · 60 days
- Still alive at the end of the study period (60 days), of 63 enrolled
- 24 (38%)
Duration of invasive mechanical ventilation before inclusion
- Median days of invasive mechanical ventilation before inclusion
- 4 days (3-6)
Original publication
Diaphragm function in patients with Covid-19-related acute respiratory distress syndrome on venovenous extracorporeal membrane oxygenation. Ann Intensive Care. Published 26 September 2023. doi:10.
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