Clinical impact of hypermagnesemia in acute kidney injury patients undergoing continuous kidney replacement therapy: A propensity score analysis utilizing real-world data
Main finding · Non-recovery of renal functionResult — go to the resultOdds ratio 1.01 95 % CI 0.90–1.14Authors' conclusion
Our study suggests that hypermagnesemia in AKI patients undergoing CKRT is not associated with improved renal recovery but is linked to worse clinical outcomes, including all-cause mortality and arrhythmia.
Study context
- Population
- Acute kidney injury (AKI) patients undergoing continuous kidney replacement therapy (CKRT), multicentre repository, 2001–2019
- Participants
- 2,625 patients
- Exposure
- Hypermagnesemia vs normomagnesemia at CKRT initiation
- Outcome
- Non-recovery of renal function
- Follow-up
- 90 days
Methodological detailsmulticentre, propensity score analysis
- Multicentre
- Propensity score analysis
Main finding
As reported in the abstract
Odds ratio
1.01
95 % CI 0.90–1.14
By group
Hypermagnesemia vs Normomagnesemia
OR 1.01 (95 % CI 0.90–1.14)
Observational data: associations, not effects.
Further findings
- Higher 1-year all-cause mortality in the high magnesium group
- HR 1.14, 95 % CI 1.07-1.21
Safety
Arrhythmia · 1 year
- Elevated risk of 1-year arrhythmia in the high magnesium group
- HR 4.77, 95 % CI 1.59-14.29
Seizure
- No difference in seizure incidence between hypermagnesemia and normomagnesemia
Original publication
Clinical impact of hypermagnesemia in acute kidney injury patients undergoing continuous kidney replacement therapy: A propensity score analysis utilizing real-world data. J Crit Care. Published 9 November 2024. doi:10.
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