Clinical impact of the implementation of monocyte distribution width (MDW) measurement on time to anti-infective administration in sepsis patients in the emergency department: a before/after cohort study
Authors' conclusion
Implementing POC MDW measurement in the ED protocols enhances the timeliness of anti-infective administration from sepsis onset, meeting current sepsis management guidelines.
Study context
- Population
- Sepsis patients in the emergency department (ED) of an academic hospital in Paris
- Participants
- 255 vs 180
- Exposure
- Point-of-care MDW measurement in the ED vs before implementation
- period-1n = 255reference
- period-2n = 180
- Outcome
- Time to anti-infectious administration (TTA) from ED arrival
Methodological detailssingle-centre, academic hospital
- Single-centre
- Academic hospital
Main finding
As reported in the abstract
TTA from ED arrival
P = 0.06
Observational data: associations, not effects.
Secondary outcomes
TTA from sepsis onset (TTAS)
P < 0.001
Mortality
P = 0.4
Hospitalisation rate
P = 0.4
| Outcome | period-1 | period-2 | P value |
|---|---|---|---|
| ED LOS | 7.2 (range 5.3–9.8) h | 7.0 (range 5.4–9.4) | P = 0.7 |
Original publication
Clinical impact of the implementation of monocyte distribution width (MDW) measurement on time to anti-infective administration in sepsis patients in the emergency department: a before/after cohort study. Crit Care. Published 27 October 2024. doi:10.
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