Respiratory failure & ventilation
Clinical risk factors for increased respiratory drive in intubated hypoxemic patients
Authors' conclusion
Independent clinical risk factors for higher respiratory drive in intubated hypoxemic patients include the extent of lung edema and of ventilation-perfusion mismatch, lower pHa, and lower PEEP, while sedation strategy does not affect drive.
Study context
- Population
- Intubated hypoxemic patients on pressure support (PS) with simultaneous P0.1 and risk factor assessment on day 1
- Participants
- 217 patients
- Primary endpoint
- Independent correlation of clinical risk factors with respiratory drive (P0.1)
- Follow-up
- Day 1
Methodological detailsphysiological dataset
- Physiological dataset
Primary result
As reported in the abstract
Clinical risk factors independently correlated with P0.1
- Bilateral infiltrates · higher P0.1
- increase ratio (IR) 1.233 (95% CI 1.047–1.451); P = 0.012
- PaO2/FiO2 · lower PaO2/FiO2 with higher P0.1
- increase ratio (IR) 0.998 (95% CI 0.997–0.999); P = 0.004
- Ventilatory ratio · higher ventilatory ratio with higher P0.1
- increase ratio (IR) 1.538 (95% CI 1.267–1.867); P < 0.001
- pHa · lower pHa with higher P0.1
- increase ratio (IR) 0.104 (95% CI 0.024–0.464); P = 0.003
- PEEP · higher PEEP with lower P0.1
- increase ratio (IR) 0.951 (95% CI 0.921–0.982); P = 0.002
Original publication
Clinical risk factors for increased respiratory drive in intubated hypoxemic patients. Crit Care. Published 11 April 2023. doi:10.
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