Respiratory failure & ventilation
Prolonged vs shorter awake prone positioning for COVID-19 patients with acute respiratory failure: a multicenter, randomised controlled trial
Authors' conclusion
Prolonged awake prone positioning of patients with COVID-19-related AHRF reduces the intubation rate without significant harm.
Study context
- Population
- Non-intubated patients with COVID-19-related acute hypoxemic respiratory failure, 12 hospitals in China
- Participants
- 409 patients
- Comparison
- Prolonged awake prone positioning vs Standard care
- Prolonged awake prone positioningn = 205
- Standard caren = 204reference
- Primary endpoint
- Endotracheal intubation
- Follow-up
- 28 days after randomization
Methodological detailsopen-label, multicentre
- Open-label
- Multicentre
Primary result
As reported in the abstract
Each group vs standard careEstimate (95% CI)
Prolonged awake prone positioning
RR 0.62(0.42–0.9)
Prolonged awake prone positioning
HR 0.56(0.37–0.86)
Secondary outcomes
| Outcome | HR (CI) | |
|---|---|---|
| Mortality · 28 days | 0.63 (0.42–0.96) | |
| 0.512Hazard ratio (log scale) |
Duration of prone positioning · first 7 days
Safety
Pre-specified adverse events
- Incidence low and similar in both groups
Original publication
Prolonged vs shorter awake prone positioning for COVID-19 patients with acute respiratory failure: a multicenter, randomised controlled trial. Intensive Care Med. Published 1 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →