Hemodynamics, fluids & transfusion
Clot formation risk in the clearing fluid after arterial catheter blood sampling: coagulation factors consumption over time - a prospective pilot study
Authors' conclusion
Although no macroscopic clots were observed in the clearing fluid, its coagulation factors decreased over the 5 min following reservoir filling, indicating potential initiation of clot formation.
Study context
- Population
- Adult ICU patients with a radial artery catheter requiring hemostasis measurements; locally developed closed blood sampling system120 samples analysed
- Participants
- Thirty patients
- Exposure
- Clearing fluid at 2, 3 and 5 min vs patients' pure blood
- Outcome
- Fibrinogen consumption in the clearing fluid as an indicator of clot formation over time
Methodological detailssingle-group, repeated measurements, Antiplatelet agent administered in 11 (37%) patients, Unfractionated heparin anti-Xa activity >0.10 UI/ml in 17 (57%)
- Single-group
- Repeated measurements
- Antiplatelet agent administered in 11 (37%) patients
- Unfractionated heparin anti-Xa activity >0.10 UI/ml in 17 (57%)
Main finding
As reported in the abstract
Fibrinogen level
| Group | Value | P vs reference |
|---|---|---|
| Reference | median 4.3 (IQR 3.1–5.9) g/L | |
| 2 min | median 3.6 (IQR 2.7–4.7) g/L | p < 0.001 |
| 3 min | median 3.4 (IQR 2.1–4.3) g/L | p < 0.001 |
| 5 min | median 3.0 (IQR 1.7–4.1) g/L | p < 0.001 |
Value
Referencemedian 4.3 (IQR 3.1–5.9) g/L
2 minmedian 3.6 (IQR 2.7–4.7) g/L
3 minmedian 3.4 (IQR 2.1–4.3) g/L
5 minmedian 3.0 (IQR 1.7–4.1) g/L
P vs reference
Reference— not stated in the abstract
2 minp < 0.001
3 minp < 0.001
5 minp < 0.001
Observational data: associations, not effects.
Safety
Macroscopic clots in clearing fluid
- No clot macroscopically detected in any samples
Original publication
Clot formation risk in the clearing fluid after arterial catheter blood sampling: coagulation factors consumption over time - a prospective pilot study. J Clin Monit Comput. Published 12 December 2024. doi:10.
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