Cocaine to prevent bleeding during nasotracheal intubation: A systematic review
Pooled result · Occurrence of epistaxisResult — go to the resultRelative risk 0.90 95% CI 0.75–1.09Authors' conclusion
This systematic review with meta-analysis demonstrated that the quantity and certainty of evidence on cocaine used for nasotracheal intubation is low and that there is no firm evidence for the benefits and harms of cocaine compared to other vasoconstrictors and topical analgetics or placebo.
Study context
- Population
- Patients undergoing nasotracheal intubation
- Participants
- 457 patients · 6 RCTs
- Comparison
- Nasal cocaine vs active comparators or placebo
- Outcome
- Occurrence and severity of epistaxis
Methodological detailspredefined protocol, PRISMA, Cochrane Risk of Bias 2, GRADE
- Predefined protocol
- PRISMA
- Cochrane Risk of Bias 2
- GRADE
Pooled result
Occurrence of epistaxis
Relative risk
0.90
95% CI 0.75–1.09
Cocaine vs Comparators
RR 0.90 (95% CI 0.75–1.09)
As reported in the abstract
Further pooled results
- No studies reported on pain or mechanical complications; data on patient-centred side effects sparse
Original publication
Cocaine to prevent bleeding during nasotracheal intubation: A systematic review. Acta Anaesthesiol Scand. Published 16 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →