Cocaine versus xylometazoline to prevent epistaxis after nasotracheal intubation: A randomized trial
Primary result · BleedingResult — go to the resultDifference 9.0 % 95% CI −9.4% to 27%Authors' conclusion
We found no statistically significant difference between cocaine and xylometazoline in preventing epistaxis after nasotracheal intubation
Study context
- Population
- Patients scheduled for surgery under GA with nasotracheal intubation
- Participants
- 49 vs 53
- Comparison
- Xylometazoline vs cocaine as decongestant before nasotracheal intubation
- Xylometazolinen = 49
- Cocainen = 53reference
- Primary endpoint
- Epistaxis (bleeding) immediately after nasotracheal intubation, four-point scale
- Follow-up
- Immediately following intubation
Methodological detailssingle-centre, outcome assessor and analyst-blinded
- Single-centre
- Outcome assessor and analyst-blinded
Primary result
Bleeding
Difference
9.0 %
95% CI −9.4% to 27%
P = 0.41
Events by treatment group
Xylometazoline vs Cocaine
difference 9.0 % (95% CI −9.4% to 27%); P = 0.41
As reported in the abstract
Further findings
Heart rate and BP (first 5 min after drug administration)
- No statistically significant difference between groups
Safety
Events
| Outcome | Cocaine | Xylometazoline |
|---|---|---|
| Adverse cardiac events · 24 h | 0 | 0 |
Original publication
Cocaine versus xylometazoline to prevent epistaxis after nasotracheal intubation: A randomized trial. Acta Anaesthesiol Scand. Published 25 June 2024. doi:10.
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