Cardiothoracic & vascular anesthesia
Cognitive Training for Reduction of Delirium in Patients Undergoing Cardiac Surgery: A Randomized Clinical Trial
Primary resultResult — go to the resultAdjusted odds ratio 0.43 95% CI 0.23–0.77Authors' conclusion
In this randomized trial of 208 patients undergoing coronary artery bypass grafting, preoperative cognitive training reduced the incidence of postoperative delirium.
Study context
- Population
- Patients scheduled for elective CABG, enrolled at least 10 days before surgery, southeastern China, April 2022–May 2023208 analysed
- Participants
- 218 patients
- Comparison
- Preoperative cognitive training vs routine care
- Cognitive trainingn = 102
- Routine caren = 106reference
- Primary endpoint
- Delirium (Confusion Assessment Method or CAM-ICU)
- Follow-up
- POD 1 to 7 or until hospital discharge
Methodological detailsprospective, single-blind, multicentre (3 university teaching hospitals), stratified by site
- Prospective
- Single-blind
- Multicentre (3 university teaching hospitals)
- Stratified by site
Primary result
As reported in the abstract
Adjusted odds ratio
0.43
95% CI 0.23–0.77
P = 0.007
Events by treatment group
Cognitive training vs Routine care
aOR 0.43 (95% CI 0.23–0.77); P = 0.007
Secondary outcomes
| Outcome | aOR (95% CI) | P value | |
|---|---|---|---|
| Severe delirium | 0.46 (0.25–0.82) | P = 0.01 | |
| 0.20.5125Adjusted odds ratio (log scale) |
Median, days
| Outcome | Cognitive training | Routine care | P value |
|---|---|---|---|
| Duration of delirium | 0 (IQR 0–1) | 0 (IQR 0–2) | P = 0.008 |
| Number of delirium-positive days | 0 (IQR 0–1) | 0 (IQR 0–2) | P = 0.007 |
Other secondary outcomes (POCD, 30-day all-cause mortality)
- No other secondary outcomes differed significantly
Original publication
Cognitive Training for Reduction of Delirium in Patients Undergoing Cardiac Surgery: A Randomized Clinical Trial. JAMA Netw Open. Published 1 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →