Combination of Cv-aCO2/Ca-vO2 and Pv-aCO2 as markers of resuscitation or microcirculation in patients with septic shock: a pilot study
Authors' conclusion
The combined assessment of Cv-aCO2/Ca-vO2 and Pv-aCO2 during the early stages of resuscitation demonstrates a significant association with mortality in septic shock patients.
Study context
- Population
- Newly diagnosed septic shock patients admitted to intensive care unit (ICU), May 2023–August 2024
- Participants
- 105 participants
- Exposure
- Four groups by Cv-aCO2/Ca-vO2 and Pv-aCO2 levels at 6 h post-ICU admission
- Outcome
- 28-day mortality
- Follow-up
- 28 days
Methodological detailssingle-centre, exploratory, pilot
- Single-centre
- Exploratory
- Pilot
Main finding
As reported in the abstract
- 28-day mortality differed significantly among the four groups
- P < 0.05
- Kaplan-Meier 28-day survival probabilities differed significantly
- P = 0.014
Observational data: associations, not effects.
Further findings
Independent risk factors for 28-day mortality (multivariate Cox regression)
| HR (95% CI) | P value | ||
|---|---|---|---|
| Age | 1.05 (1.02–1.09) | P = 0.001 | |
| Cv-aCO2/Ca-vO2 | 1.67 (1.03–2.69) | P = 0.036 | |
| Pv-aCO2 | 1.13 (1.00–1.27) | P = 0.043 | |
| 0.20.5125Hazard ratio (log scale) |
Sublingual microcirculation (PPV, sPPV, microvascular flow index (MFI), heterogeneity index (HI))
- Significant differences among the four groups in PPV, sPPV, MFI and HI
- P < 0.001
- Correlation Cv-aCO2/Ca-vO2 and sPPV
- r = −0.49, p < 0.001, R2 = 0.19
- Correlation Pv-aCO2 and sPPV
- r = −0.22, p = 0.028, R2 = 0.08
Original publication
Combination of Cv-aCO2/Ca-vO2 and Pv-aCO2 as markers of resuscitation or microcirculation in patients with septic shock: a pilot study. J Intensive Care. Published 17 June 2025. doi:10.
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