Comparison of all-cause mortality with different blood glucose control strategies in patients with diabetes in the ICU: a network meta-analysis of randomized controlled trials

Li, X; Meng, J; Dai, X; Liu, P; Wu, Y; Wang, S; Yin, H; Gao, S

doi:10.1186/s13613-025-01471-x

Organ support & nutrition

Comparison of all-cause mortality with different blood glucose control strategies in patients with diabetes in the intensive care unit (ICU): a network meta-analysis of randomized controlled trials

Ann Intensive CarePublished 9 Apr 2025Network meta-analysis of randomised controlled trials

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Authors' conclusion

In ICU patients with diabetes, no significant statistical difference was observed among the four glucose control strategies in reducing all-cause 90-day mortality.

Study context

Population: ICU patients with diabetes
Participants: 5,297 patients · 12 RCTs

Comparison: Strict vs intermediate strict vs liberal vs very liberal glucose control
Outcome: All-cause mortality
Follow-up: 90 days

Methodological detailsRisk of Bias 2 tool, surface under the cumulative ranking (SUCRA) ranking

Risk of Bias 2 tool
SUCRA ranking

Pooled result

As reported in the abstract

All-cause 90-day mortality

Intermediate strict control88%

Liberal control55.3%

Very liberal control40.3%

Strict control16.5%

Original publication

Comparison of all-cause mortality with different blood glucose control strategies in patients with diabetes in the ICU: a network meta-analysis of randomized controlled trials. Ann Intensive Care. Published 9 April 2025. doi:10.1186/s13613-025-01471-x

Read the original article ↗

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