Comparison of Clinical Outcomes and Postoperative Nutritional Status Between Early and Late Oral Feeding After Esophagectomy: An Open Labeled Randomized Controlled Trial
Authors' conclusion
The late group demonstrated prevention of significant body weight loss, enhanced nutritional intake, and reduced malnutrition without compromising short-term surgical outcomes.
Study context
- Population
- Patients aged 18 to 75 years with resectable esophageal cancer undergoing esophagectomy
- Participants
- 29 vs 29
- Comparison
- Early vs Late
- Earlyn = 29reference
- Laten = 29
- Primary endpoint
- Body weight loss from preoperative body weight
- Follow-up
- Postoperative 4 to 5 weeks and 4 months
Methodological detailssingle-centre, prospective, open-label
- Single-centre
- Prospective
- Open-label
Primary result
As reported in the abstract
Body weight loss
- Significantly less body weight loss in the late group at both time points
- Late vs Early: P = 0.002
- Late vs Early: P = 0.003
Further findings
Change to malnutrition state
| Outcome | P value |
|---|---|
| Total calorie intakePostoperative 4 to 5 weeks: 1800 kcal/day vs. 1100 kcal/day | P < 0.001 |
| Total calorie intake4 months: 1565 kcal/day vs. 1200 kcal/day | P = 0.010 |
Total calorie intake
- Total calorie and protein intake higher in the late group at both time points
Length of hospital stay
- Similar in the two groups
Safety
Complication rate
- Similar in the two groups
Original publication
Comparison of Clinical Outcomes and Postoperative Nutritional Status Between Early and Late Oral Feeding After Esophagectomy: An Open Labeled Randomized Controlled Trial. Ann Surg. Published 12 July 2024. doi:10.
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