Hemodynamics, fluids & transfusion
Comparison of ROTEM® Delta and ROTEM® Sigma transfusion algorithm performance in thoracic aortic surgery: a single-centre prospective observational cohort study
Authors' conclusion
ROTEM® Sigma can be used with existing ROTEM-guided transfusion algorithms in cardiothoracic surgery except for the advice for administration of plasma or PCC.
Study context
- Population
- Patients undergoing thoracic aortic surgery102 with matched post-protamine measurements
- Participants
- 111 patients
- Exposure
- ROTEM Sigma vs ROTEM Delta
- Outcome
- Percentage of patients who would have received a different haemostatic intervention after protamine reversal per institutional ROTEM-guided transfusion algorithm ('deviation'); 10% deviation deemed acceptable
- Follow-up
- After protamine reversal
Methodological detailssingle-centre, method comparison
- Single-centre
- Method comparison
Main finding
As reported in the abstract
Algorithm deviations · post-protamine
Algorithm deviations
43
Deviations on CT EXTEM-based plasma or PCC administration
29
Delta advised plasma or PCC, Sigma did not
25
Sigma advised plasma or PCC, Delta did not
4
Observational data: associations, not effects.
Secondary outcomes
Numerical ROTEM variables (Passing-Bablok, Bland-Altman)
- All passed equivalence except A10 FIBTEM at baseline and A10 EXTEM in heparinised and post-protamine samples, without clinical consequences
Correlation with conventional coagulation tests
- Similar or better for Sigma vs Delta
Original publication
Comparison of ROTEM® Delta and ROTEM® Sigma transfusion algorithm performance in thoracic aortic surgery: a single-centre prospective observational cohort study. Br J Anaesth. Published 2 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →