Cardiothoracic & vascular anesthesia
Rotational Thromboelastometry–Guided Use of Synthetic Blood Products in Cardiac Transplant Patients: A Retrospective Before-After Study
Main finding · Time from CPB separation to skin closureResult — go to the resultDecrease 39.4 minutes CI −73.1 to 123.5Authors' conclusion
The introduction of a ROTEM-guided factor-concentrate transfusion algorithm was associated with a significant reduction in time to chest closure after separation from CPB.
Study context
- Population
- Cardiac transplant recipients, Saint Paul's Hospital, Vancouver, Canada
- Participants
- 28 vs 21
- Exposure
- After vs Before
- Aftern = 28
- Beforen = 21reference
- Outcome
- Duration from cardiopulmonary bypass (CPB) separation to chest closure
Methodological detailsbefore-after, single-centre
- Before-after
- Single-centre
Main finding
Time from CPB separation to skin closure
Decrease
39.4 minutes
CI −73.1 to 123.5
P = 0.016
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Estimate | P value |
|---|---|---|
| pRBC transfusion · within 24 hours of surgeryNot statistically significant after adjustment | −1.3 units (CI −2.7 to 0.1) | P = 0.077 |
| Chest tube bleedingNot statistically significant after adjustment | −0.44 mL (CI −0.96 to +0.083) | P = 0.097 |
Hospital LOS
- Median hospital LOS in the study group lower by 3 days (13 days v 16 days)
- P = 0.048
ICU LOS
- No difference in ICU LOS
Original publication
Rotational Thromboelastometry–Guided Use of Synthetic Blood Products in Cardiac Transplant Patients: A Retrospective Before-After Study. J Cardiothorac Vasc Anesth. Published 4 March 2023. doi:10.
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