Cardiothoracic & vascular anesthesia
Dose-Dependent Changes in Clot Firmness in Thromboelastometry After Administration of Fibrinogen Concentrate: A Retrospective Observational Study
Authors' conclusion
Body weight-based fibrinogen dosing allows predictions of the mean changes in A5. Total, ideal, and lean body weights yielded similar correlation coefficients.
Study context
- Population
- Cardiac surgery patients with 2 intraoperative rotational thromboelastometry (ROTEM) examinations receiving coagulation factors, tertiary academic cardiac hospital, May 2022–August 2024
- Participants
- 180 patients
- Outcome
- Increase in A5 per 10 mg/kg FC (linear regression)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Total body weight: mean increase in A5 per 10 mg/kg fibrinogen concentrate (FC) 1.37 mm
1.37
95% CI 1.12–1.53 mm
Ideal body weight: mean increase in A5 per 10 mg/kg FC 1.20 mm
1.20
95% CI 1.08–1.33 mm
Lean body weight: mean increase in A5 per 10 mg/kg FC 1.02 mm
1.02
95% CI 0.9–1.13 mm
Observational data: associations, not effects.
Further findings
A5 ≤12 mm for predicting hypofibrinogenemia (ROC)
- Sensitivity
- 77%
- Specificity
- 94%
Prediction of excessive blood loss
- No thresholds predicted excessive blood loss
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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