Comparison of the effects of sugammadex versus neostigmine for reversal of neuromuscular block on hospital costs of care
Main finding · Direct costs (registry data)Result — go to the resultDifference −1.3 % 95% CI −0.5 to −2.2%Authors' conclusion
The effects of using sugammadex on costs of care depend on patient risk, defined based on comorbidities and admission status. We observed lower costs of care in patients with lower risk and higher costs of care in hospitalised surgical patients with severe comorbidities.
Study context
- Population
- Adult surgical patients receiving NMBAs and reversal, two academic healthcare networks, 2016–2021
- Participants
- 79,474 patients
- Exposure
- Sugammadex vs neostigmine for reversal of NMB
- Outcome
- Hospital costs of care (direct costs; total costs in US dollars)
Methodological detailstwo academic healthcare networks, registry data, Healthcare Cost and Utilization Project-National Inpatient Sample (HCUP-NIS) matched cohort
- Two academic healthcare networks
- Registry data
- HCUP-NIS matched cohort
Main finding
Direct costs (registry data)
Difference
−1.3 %
95% CI −0.5 to −2.2%
P = 0.002
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Difference (US$) (95% CI) | P value | |
|---|---|---|---|
| Total costs, higher-risk patients (ASA ≥3 and preoperative hospitalisation) (subgroup)Higher total costs | 620 (US$377 to US$865) | P < 0.001 | |
| −50005001000Difference, US$ (linear scale) |
| Outcome | Difference (US$) (95% CI) | P value |
|---|---|---|
| Total costs (HCUP-NIS matched cohort)Lower total costs · matched cohort | 232 (-US$376 to -US$88) | P = 0.002 |
| Total costs, lower-risk patients (subgroup)Lower total costs | 1042 (-US$1198 to -US$884) | P < 0.001 |
Original publication
Comparison of the effects of sugammadex versus neostigmine for reversal of neuromuscular block on hospital costs of care. Br J Anaesth. Published 21 December 2022. doi:10.
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