The effects of sugammadex vs. neostigmine on postoperative respiratory complications and advanced healthcare utilisation: a multicentre retrospective cohort study
Main findingResult — go to the resultAdjusted odds ratio 1.01 95% CI 0.94–1.08Authors' conclusion
Compared with neostigmine, reversal of neuromuscular blockade with sugammadex was not associated with a reduction in postoperative respiratory complications or post-procedural advanced healthcare utilisation.
Study context
- Population
- Adults undergoing surgery under GA with sugammadex or neostigmine reversal, two academic healthcare networks, January 2016–June 2021
- Participants
- 83,250 adults
- Exposure
- Sugammadex vs neostigmine reversal of NMB
- Outcome
- Postoperative respiratory complications (post-extubation SpO2 < 90%, respiratory failure requiring NIV, or tracheal re-intubation)
- Follow-up
- Within 7 days
Methodological detailsmulticentre, two academic healthcare networks
- Multicentre
- Two academic healthcare networks
Main finding
As reported in the abstract
Adjusted odds ratio
1.01
95% CI 0.94–1.08
P = 0.76
Sugammadex vs Neostigmine
aOR 1.01 (95% CI 0.94–1.08); P = 0.76
- Postoperative respiratory complications, all patients
- 5746 (6.9%)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | aOR (95% CI) | P value | |
|---|---|---|---|
| Advanced healthcare utilisation (7-day unplanned ICU admission, 30-day readmission or non-home discharge; main secondary)Excluding patients admitted from skilled nursing facilities | 0.95 (0.89–1.01) | P = 0.11 | |
| 0.512Adjusted odds ratio (log scale) |
- Advanced healthcare utilisation (7-day unplanned ICU admission, 30-day readmission or non-home discharge; main secondary) — Advanced healthcare utilisation, all patients
- 8372 (10.5%)
- Advanced healthcare utilisation (7-day unplanned ICU admission, 30-day readmission or non-home discharge; main secondary): equivalence supported; neostigmine non-inferior to sugammadex
Safety
| Outcome | aOR (CI) | P value | |
|---|---|---|---|
| MACE | 1.07 (0.94–1.21) | P = 0.32 | |
| 0.512Adjusted odds ratio (log scale) |
Original publication
The effects of sugammadex vs. neostigmine on postoperative respiratory complications and advanced healthcare utilisation: a multicentre retrospective cohort study. Anaesthesia. Published 23 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →