Complement activation in severely ill patients with sepsis: no relationship with inflammation and disease severity
Authors' conclusion
Once an infection progresses to severe sepsis or septic shock, the complement pathway is already profoundly activated and is no longer related to a dysregulated inflammatory response, nor to clinical outcome.
Study context
- Population
- Hospitalized sepsis patients, majority presenting with shock
- Participants
- 209 patients
Primary result
As reported in the abstract
Complement factors (C3, C3a, C3c, C5, C5a, soluble terminal complement complex) in plasma within 24 h of sepsis diagnosis · within 24 h after sepsis diagnosis
- Profound activation of the complement system vs healthy controls
- all P < 0.01
- Complement factors not associated with SOFA score, incidence of septic shock or mortality
- all P > 0.05
Original publication
Complement activation in severely ill patients with sepsis: no relationship with inflammation and disease severity. Crit Care. Published 16 February 2023. doi:10.
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