Respiratory failure & ventilation
Complete blood count, coagulation biomarkers, and lung function 6 months after critical COVID ‐19
Authors' conclusion
Only a few patients had normal CBC and coagulation biomarker values 6 months after critical COVID-19. A weak negative correlation between DLCOc% and FVIII suggests that deranged coagulation activity may be associated with reduced diffusing capacity.
Study context
- Population
- Patients treated for COVID-19 in ICUs, 3/2020–1/2021
- Outcome
- CBC and coagulation biomarkers (PT%, activated partial thromboplastin time (APTT), fibrinogen, FVIII, AT, D-dimer), compared with acute phase and correlated with lung function (DLCOc%)
- Follow-up
- 6 months post-hospitalization
Main finding
As reported in the abstract
6 months
Full normalization of all biomarkers
21%
15/70
Factor VIII (FVIII) elevated
46%
31/68
Leukocytes elevated
26%
18/70
D-dimer elevated
27%
18/67
Observational data: associations, not effects.
Further findings
Correlation between DLCOc% and FVIII · 6 months
- Weak negative correlation (r)
- −0.37
- P
- P = 0.036
- Multivariable analysis: weak, independent association between DLCOc% and FVIII
Correlation with DLCOc%, excluding patients on anticoagulation (subgroup) · 6 months
- FVIII no longer correlated with DLCOc%; Antithrombin (AT) showed a moderate correlation
Original publication
Complete blood count, coagulation biomarkers, and lung function 6 months after critical COVID ‐19. Acta Anaesthesiol Scand. Published 9 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →