Respiratory failure & ventilation
Contribution and evolution of respiratory muscles function in weaning outcome of ventilator-dependent patients
Authors' conclusion
Respiratory muscle function and limb muscles strength are severely impaired in patients with prolonged weaning from mechanical ventilation.
Study context
- Population
- Tracheotomized ventilator-dependent patients in prolonged weaning, admitted to a weaning centerenrolled
- Participants
- 60 patients
- Exposure
- Complete weaning vs partial weaning vs death at discharge
- Complete weaningn = 30
- Partial weaningn = 20
- Deathn = 10
- Outcome
- Association of change in respiratory muscles function and limb muscles strength over time with weaning success
Methodological detailssingle-centre weaning center, weekly repeated measurements, Median 2 (1-9) assessments per patient
- Single-centre weaning center
- Weekly repeated measurements
- Median 2 (1-9) assessments per patient
Main finding
As reported in the abstract
- Ptr,stim, maximal inspiratory pressure (MIP), TFdi and EXdi at admission not different between complete weaning and counterparts
- At discharge, MIP, Ptr,stim and EXdi significantly increased in complete weaning
- MRC score significantly increased only in complete weaning
Observational data: associations, not effects.
Further findings
- Diaphragm dysfunction at discharge (Ptr,stim < 11 cmH2O) — Complete weaning
- 37%
- Diaphragm dysfunction at admission (median Ptr,stim, all patients): All patients median 5.5 (range 3.0–7.5) cmH2O
Diaphragm dysfunction at admission (median Ptr,stim, all patients)
- Diaphragm dysfunction present in all patients
Outcome at 6 months
- Lost to follow-up
- 6
- Complete weaning
- 33
- Partial weaning
- 10
- Died
- 11
Original publication
Contribution and evolution of respiratory muscles function in weaning outcome of ventilator-dependent patients. Crit Care. Published 18 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →