Respiratory failure & ventilation
Computational physiological models for individualised mechanical ventilation: a systematic literature review focussing on quality, availability, and clinical readiness
Authors' conclusion
CPMs are advancing towards clinical application as an explainable tool to optimise individualised MV.
Study context
- Population
- Original research articles describing computational physiological models (CPMs) for individualised mechanical ventilation in the ICUpublications included
- Participants
- 149 participants
- Outcome
- Modelled physiological phenomena, applications, readiness and reporting quality
Methodological detailsquality assessment based on American Society of Mechanical Engineers (ASME) standards, Search 13 February 2023 in MEDLINE ALL, Embase, Scopus and Web of Science; 6,333 unique publications screened
- Quality assessment based on ASME standards
- Search 13 February 2023 in MEDLINE ALL, Embase, Scopus and Web of Science; 6,333 unique publications screened
Main finding
As reported in the abstract
- Lung mechanics models, mainly for lung-protective ventilation (articles)
- 131 (88%)
- Gas exchange models (articles)
- 38 (26%)
- Gas homeostasis models (articles)
- 36 (24%)
- Respiratory muscle function models for diaphragm-protective ventilation, emerged recently (articles)
- 3 (2%)
- RCTs initiated (Beacon and CURE Soft models, gas exchange and PEEP optimisation)
- 3
- Model design reported unsatisfactory (articles)
- 93%
- Model quality reported unsatisfactory (articles)
- 21%
Original publication
Computational physiological models for individualised mechanical ventilation: a systematic literature review focussing on quality, availability, and clinical readiness. Crit Care. Published 6 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →