Respiratory failure & ventilation
Is acute respiratory distress syndrome a preventable disease?
Study context
- Population
- Acute respiratory distress syndrome (ARDS) prevention literature (clinical trials, population-based epidemiologic studies, implementation research, biological subphenotyping studies)
- Outcome
- Preventability of ARDS
Main finding
As reported in the abstract
- Iatrogenic phenotypes: ARDS prevention has substantially succeeded
- Transfusion-related acute lung injury declined dramatically after male-predominant plasma policies
- Lung-protective ventilation started in ED and operating rooms reduced ARDS incidence and mortality
- Bundled care (restrictive fluid and transfusion, aspiration precautions, early antimicrobials) further reduced iatrogenic lung injury
- Pharmacologic prevention trials in unselected populations consistently disappointing, likely because subphenotypes respond differently
- Population-attributable fraction of death from ARDS is modest; successful prevention may not give proportional mortality reduction
Original publication
Is acute respiratory distress syndrome a preventable disease? Intensive Care Med. Published 8 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →