Perioperative medicine & outcomes
Contribution of intraoperative electroencephalogram suppression to frailty-associated postoperative delirium: mediation analysis of a prospective surgical cohort
Authors' conclusion
EEG suppression time mediated a statistically significant portion of the frailty-POD association in older noncardiac surgery patients.
Study context
- Population
- Patients aged ≥65 yr scheduled for noncardiac surgery under TIVAenrolled
- Participants
- 252 patients
- Exposure
- Frail vs prefrail vs robust; mediation by intraoperative EEG suppression
- Robustn = 51reference
- Prefrailn = 129
- Frailn = 72
- Outcome
- Proportion of the frailty–postoperative delirium (POD) severity (DRS) association mediated by cumulative EEG suppression time (amplitude −5 to 5 μV for >0.5 s)
Main finding
As reported in the abstract
EEG suppression time as mediator of frailty–DRS score association
Proportion of frailty–DRS score association mediated by EEG suppression time
24.2%
Observational data: associations, not effects.
Further findings
Duration of EEG suppression — Frail vs Robust
P < 0.001
| Outcome | Robust | Prefrail | Frail | P value |
|---|---|---|---|---|
| Duration of EEG suppressionFrail vs Prefrail | P < 0.001 | |||
| Peak delirium score (DRS)Frail vs Robust | 15 | 16 | 17 | P < 0.001 |
| Peak delirium score (DRS)Frail vs Prefrail | P = 0.007 |
Original publication
Contribution of intraoperative electroencephalogram suppression to frailty-associated postoperative delirium: mediation analysis of a prospective surgical cohort. Br J Anaesth. Published 9 December 2022. doi:10.
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