Correlation between tissue Doppler-derived left ventricular systolic velocity (S’) and left ventricle ejection fraction in sepsis and septic shock: a retrospective cohort study
Authors' conclusion
Even though mitral S' and LVEF may be related, they are not exchangeable and were only found to have moderate correlation in this study. LVEF is U-shaped, while mitral S' has a linear relation with 28-day ICU mortality. An increase in average mitral S' was associated with higher 28-day mortality.
Study context
- Population
- Adults (≥ 18 years) admitted to the medical ICU with sepsis and septic shock who underwent TTE within 72 h, 01/2011–12/2020
- Participants
- 2,519 adults
- Outcome
- Correlation between average mitral S' and LVEF
Main finding
As reported in the abstract
Correlation of mitral S' with LVEF
Moderate correlation of mitral S' with left ventricular ejection fraction (LVEF) (Pearson r)
0.46
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| 28-day ICU mortality, per increase in average mitral S' (multivariable logistic regression) | 1.04 (1.01–1.08) | P = 0.02 | |
| In-hospital mortality, per increase in average mitral S' (multivariable logistic regression) | 1.04 (1.01–1.07) | P = 0.02 | |
| 0.512Odds ratio (log scale) |
Median septal, lateral and average mitral S'
- Septal mitral S', median cm/s (IQR 6.0, 10.0)
- 8
- Lateral mitral S', median cm/s (IQR 6.0, 10.0)
- 9
- Average mitral S', median cm/s (IQR 6.5, 10.5)
- 8.5
Original publication
Correlation between tissue Doppler-derived left ventricular systolic velocity (S’) and left ventricle ejection fraction in sepsis and septic shock: a retrospective cohort study. J Intensive Care. Published 3 July 2023. doi:10.
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