ICU sedation, delirium & recovery
Daytime dexmedetomidine sedation with closed-loop acoustic stimulation alters slow wave sleep homeostasis in healthy adults
Main finding · N3 (SWS) duration, post-sedation vs pre-sedation sleepResult — go to the resultMean difference −17.1 min 95% CI −30.0 to −8.2Authors' conclusion
Daytime dexmedetomidine sedation and closed-loop acoustic stimulation targeting EEG slow waves reduced N3/SWS duration and measures of slow wave pressure dissipation on the post-sedation night in healthy young adults.
Study context
- Population
- Healthy participants
- Participants
- 13 participants
- Comparison
- Post-sedation sleep vs Pre-sedation sleep
- Outcome
- N3 (slow wave sleep (SWS)) duration, post-sedation vs pre-sedation sleep
- Follow-up
- Post-sedation night
Methodological detailspre-post (within-participant), in-home sleep EEG, closed-loop acoustic stimulation
- Pre-post (within-participant)
- In-home sleep EEG
- Closed-loop acoustic stimulation
Main finding
As reported in the abstract
Mean difference
−17.1 min
95% CI −30.0 to −8.2
P = 0.015
Post-sedation sleep vs Pre-sedation sleep
mean difference −17.1 min (95% CI −30.0 to −8.2); P = 0.015
Original publication
Daytime dexmedetomidine sedation with closed-loop acoustic stimulation alters slow wave sleep homeostasis in healthy adults. BJA Open. Published 28 March 2024. doi:10.
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