Breathe–squeeze: pharmacodynamics of a stimulus-free behavioural paradigm to track conscious states during sedation☆

Guay, CS; Hight, D; Gupta, G; Kafashan, M; Luong, AH; Avidan, MS; Brown, EN; Palanca, BJA

doi:10.1016/j.bja.2023.01.021

Breathe–squeeze: pharmacodynamics of a stimulus-free behavioural paradigm to track conscious states during sedation☆

Br J AnaesthPublished 24 Mar 2023Secondary analysis of the Closed-Loop Acoustic Stimulation during Sedation with Dexmedetomidine study

Read the original article ↗PubMed

Cite

Authors' conclusion

The breathe-squeeze task can effectively track changes in responsiveness during sedation without external stimuli and might be more sensitive to state changes than stimulus-based tasks.

Study context

Population: Healthy volunteers sedated with dexmedetomidine
Participants: 14 healthy volunteers

Comparison: Estimated dexmedetomidine Ce at loss of responsiveness (LOR) vs return of responsiveness (ROR)
Primary endpoint: Estimated dexmedetomidine effect-site (Ce) concentration at LOR vs ROR

Methodological detailstarget-controlled infusion, 64-channel EEG

Target-controlled infusion
64-channel EEG

Primary result

As reported in the abstract

Estimated dexmedetomidine Ce

LOR0.92mean · 95% CI 0.69–1.15 · ng ml-1

ROR1.43mean · 95% CI 1.27–1.58 · ng ml-1

P = 0.002

Further findings

LOR: progressively increasing fronto-occipital EEG power in 0.5-8 Hz band; loss of occipital alpha (8-12 Hz) and global beta (16-30 Hz) power
EEG changes reverted at ROR

Original publication

Breathe–squeeze: pharmacodynamics of a stimulus-free behavioural paradigm to track conscious states during sedation☆. Br J Anaesth. Published 24 March 2023. doi:10.1016/j.bja.2023.01.021

Read the original article ↗

Composed by AI from the published abstract and checked against it. How Briefs are made →