Hemodynamics, fluids & transfusion
Decoding portal vein pulsatility: hemodynamic determinants in a post-hoc analysis of a prospective observational trial
Authors' conclusion
RV function and Pmsa are key determinants of PVPI.
Study context
- Population
- Mechanically ventilated patients with circulatory failure within 6 h of ICU admission after elective open-heart surgery
- Participants
- 55 participants
- Primary endpoint
- Determinants of PVPI (Pmsa and RV function parameters)
Methodological detailsechocardiography, repeated measures, Retrospectively registered
- Echocardiography
- Repeated measures
- Retrospectively registered
Primary result
As reported in the abstract
Determinants of PVPI
- At T1, all patients (robust multilinear regression, squared portal vein pulsatility index (PVPI)): RVEDA/LVEDA
- β = 10.38; p < 0.001
- At T1, all patients (robust multilinear regression, squared PVPI): RIMP
- β = - 6.54; p = 0.002
- At T1, all patients (robust multilinear regression, squared PVPI): Right ventricular (RV) S'
- β = - 0.60; p = 0.002
- All patients, repeated measures correlation Pmsa–PVPI across T1-to-T3
- ρ = 0.785; p < 0.001
- All patients, correlation Pmsa–PVPI at T1 (non-significant)
- ρ = 0.215; p = 0.115
- Fluid-responsive patients, generalized estimating equations across T1, T4, T5: Pmsa
- β = 4.19; p < 0.001
- Fluid-responsive patients, generalized estimating equations: RV S'
- β = - 5.84; p < 0.001
- Fluid-responsive patients, generalized estimating equations: RVEDA/LVEDA
- β = 34.85; p = 0.018
- Fluid-responsive patients, generalized estimating equations: RIMP
- β = - 35.28; p = 0.039
Original publication
Decoding portal vein pulsatility: hemodynamic determinants in a post-hoc analysis of a prospective observational trial. Ann Intensive Care. Published 14 June 2025. doi:10.
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