Hemodynamics, fluids & transfusion
Portal vein pulsatility is associated with the cumulative fluid balance: A post hoc longitudinal analysis of a prospective, general intensive care unit cohort
Authors' conclusion
The study findings emphasise the unique sensitivity of portal vein pulsatility index in assessing fluid balance in general ICU patients.
Study context
- Population
- Adults within 24 h of general intensive care unit (ICU) admission with expected ICU LOS >2 days514 haemodynamic evaluations
- Participants
- 145 adults
- Primary endpoint
- Portal vein pulsatility index during the ICU stay
Methodological detailsexploratory, multicentre, 4 ICUs
- Exploratory
- Multicentre
- 4 ICUs
Primary result
As reported in the abstract
Factors associated with portal vein pulsatility index (multivariable mixed-effects linear regression)
- Heart rate: estimate −0.002 (95% CI −0.003 to −0.001), P < 0.001
- Cumulative fluid balance: estimate 0.0007 (95% CI 0.00007 to 0.001), P = 0.024
Secondary outcomes
Agreement of portal vein pulsatility index with other congestion markers (kappa)
- CVP ≥12 mmHg: kappa −0.008, P = 0.811
- Negative passive leg raising: kappa −0.036, P = 0.430
- Mean inferior vena caval (IVC) diameter >2 cm: kappa −0.090, P = 0.025
- Maximal IVC diameter >2 cm: kappa −0.010, P = 0.835
- Hepatic vein systolic/diastolic ratio <1: kappa 0.043, P = 0.276
- Renal vein pulsatile pattern: kappa −0.243, P < 0.001
- No agreement with any marker
Original publication
Portal vein pulsatility is associated with the cumulative fluid balance: A post hoc longitudinal analysis of a prospective, general intensive care unit cohort. Eur J Anaesthesiol. Published 16 December 2024. doi:10.
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