Hemodynamics, fluids & transfusion
Fluid balance control in critically ill patients: results from POINCARE-2 stepped wedge cluster-randomized trial
Authors' conclusion
The POINCARE-2 conservative strategy did not reduce mortality in critically ill patients.
Study context
- Population
- Mechanically ventilated adults admitted to ICU for > 48 and ≤ 72 h with expected LOS after inclusion > 24 h, 12 ICUs in 9 French hospitals1,353 completed follow-up
- Participants
- 1,361 participants
- Comparison
- POINCARE-2 fluid balance control strategy vs control
- Strategyn = 433
- Controln = 472reference
- Primary endpoint
- All-cause mortality
- Follow-up
- 60 days
Methodological detailsopen-label, multicentre, intention-to-treat
- Open-label
- Multicentre
- Intention-to-treat
Primary result
As reported in the abstract
P = 0.26
Further findings
60-day mortality, randomized before-and-after analysis (Strategy n=643, Control n=718)
- Similar results
Safety
Hypernatremia · only safety outcome more frequent in the strategy group
P = 0.01
Original publication
Fluid balance control in critically ill patients: results from POINCARE-2 stepped wedge cluster-randomized trial. Crit Care. Published 21 February 2023. doi:10.
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