Hemodynamics, fluids & transfusion
Restrictive fluid management with early de-escalation versus usual care in critically ill patients (reduce trial): a feasibility randomized controlled trial
Authors' conclusion
A restrictive fluid strategy with early de-escalation and de-resuscitation is feasible and may reduce fluid accumulation and showed a signal for reduced hospital stay without increasing adverse events in critically ill patients following acute fluid resuscitation.
Study context
- Population
- Medical ICU patients with shock requiring fluid resuscitation, after initial fluid resuscitation
- Participants
- 100 patients
- Comparison
- Restrictive fluid strategy with early de-escalation vs usual care
- Restrictiven = 50
- Usual caren = 50reference
- Primary endpoint
- Cumulative fluid balance
- Follow-up
- Day 3
Methodological detailssingle-centre, feasibility
- Single-centre
- Feasibility
Primary result
As reported in the abstract
Restrictive
−2353
mL
Usual care
793
mL
P < 0.001
Secondary outcomes
- Cumulative fluid balance · day 7 — Lower cumulative fluid balance trend continued to day 7 (restrictive vs usual care)
- −3032 mL vs. 1125 mL · P < 0.001
- ICU LOS — Shorter ICU stay in the restrictive group
- 7 vs. 10 days · P = 0.006
- Hospital LOS — Shorter hospital stay in the restrictive group
- 16 vs. 22 days · P = 0.02
- Hospital mortality — No statistically significant difference in hospital mortality between the groups · no statistically significant difference
- 18% vs. 38% · P = 0.05
- 30-day mortality · 30 days — No statistically significant difference in 30-day mortality between the groups · no statistically significant difference
- 12% vs. 30% · P = 0.05
AKI and RRT
- No significant differences in incidence of AKI or use of RRT
Safety
- No significant differences in AKI incidence or RRT use
Original publication
Restrictive fluid management with early de-escalation versus usual care in critically ill patients (reduce trial): a feasibility randomized controlled trial. Crit Care. Published 25 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →