Fluid balance control in critically ill patients: results from as-treated analyses of POINCARE-2 randomized trial
Authors' conclusion
Actual exposure to POINCARE-2 conservative strategy was not associated with reduced mortality in critically ill patients.
Study context
- Population
- Adults ≥ 18 years on mechanical ventilation with expected ICU LOS > 24 h
- Participants
- 1,361 adults
- Comparison
- Exposed vs Not exposed
- Primary endpoint
- All-cause mortality
- Follow-up
- 60-day
Methodological detailsas-treated analysis, stepped wedge, multiple imputation, instrumental variable analysis, Strategy: daily weighing over 14 days, then fluid restriction, diuretics and/or ultrafiltration
- As-treated analysis
- Stepped wedge
- Multiple imputation
- Instrumental variable analysis
- Strategy: daily weighing over 14 days, then fluid restriction, diuretics and/or ultrafiltration
Primary result
As reported in the abstract
60-day all-cause mortality · 60 days
Exposure to the POINCARE-2 strategyOdds ratio (95% CI)
ALR (logistic regression adjusted for confounders)
1.2(0.85–1.55)
IVLR (logistic regression adjusted for an instrumental variable)
1.0(0.76–1.33)
Further findings
Exposure score ≥ 75 by randomised group
Original publication
Fluid balance control in critically ill patients: results from as-treated analyses of POINCARE-2 randomized trial. Crit Care. Published 6 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →