Decreased renal cortical perfusion post-EGDT is associated with MAKE-30 in sepsis
Main finding · Renal cortical perfusion and MAKE-30Result — go to the resultHazard ratio 2.278 95 % CI 1.152–4.507Authors' conclusion
Despite normal systemic hemodynamics post-sepsis EGDT, MAKE-30 patients show reduced renal cortical perfusion.
Study context
- Population
- Sepsis patients admitted to the ICU, Jan 2022 to Jul 2023, assessed post-EGDT
- Participants
- 94 patients
- Exposure
- MAKE-30 vs non-MAKE-30
- MAKE-30n = 46
- Outcome
- Association of renal cortical perfusion (contrast-enhanced ultrasound (CEUS)) post-EGDT with MAKE-30
- Follow-up
- 30 days
Main finding
Renal cortical perfusion and MAKE-30
Hazard ratio
2.278
95 % CI 1.152–4.507
P = 0.018
MAKE-30 vs non-MAKE-30
HR 2.278 (95 % CI 1.152–4.507); P = 0.018
As reported in the abstract
- Renal microcirculation AUC lower in MAKE-30
- P = 0.035
- rBV lower in MAKE-30
- P = 0.021
- PI lower in MAKE-30
- P = 0.003
Observational data: associations, not effects.
Further findings
| Outcome | MAKE-30 | non-MAKE-30 | P value |
|---|---|---|---|
| RRI | 0.71 | 0.66 | P = 0.005 |
- Incidence of MAKE-30 · 30 days
- 48.9 % · 46
Hemodynamic parameters
- No significant differences between MAKE-30 and non-MAKE-30
Renal resistive index (RRI) vs renal cortical perfusion AUC correlation
- RRI correlated with renal cortical perfusion AUC
- r = −0.220 p 0.033
Original publication
Decreased renal cortical perfusion post-EGDT is associated with MAKE-30 in sepsis. J Crit Care. Published 6 November 2024. doi:10.
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